成人囊性纤维化患者 1 秒率下降率的风险因素。
Risk factors for rate of decline in FEV1 in adults with cystic fibrosis.
机构信息
Case Western Reserve University School of Medicine and Rainbow Babies and Children's Hospital, Cleveland, OH 44106, USA.
出版信息
J Cyst Fibros. 2012 Sep;11(5):405-11. doi: 10.1016/j.jcf.2012.03.009. Epub 2012 May 5.
Abstract
BACKGROUND
Previously we assessed risk factors for FEV(1) decline in children and adolescents using the Epidemiologic Study of Cystic Fibrosis (J Pediatr 2007;151:134-139); the current study assessed risk factors in adults.
METHODS
Risk factors for FEV(1) decline over 3-5.5 years for ages 18-24 and ≥25 years were assessed using mixed-model regression.
RESULTS
Mean rates of FEV(1) decline (% predicted/year) were -1.92 for ages 18-24y (n=2793) and -1.45 for ages ≥25y (n=1368). For the 18-24y group, B. cepacia, pancreatic enzyme use, multidrug-resistant P. aeruginosa, cough, mucoid P. aeruginosa, and female sex predicted greater decline; low baseline FEV(1) and sinusitis predicted less decline. For the ≥25y group, only pancreatic enzyme use predicted greater decline; low baseline FEV(1) and sinusitis predicted less decline.
CONCLUSIONS
Risk factors for FEV(1) decline in adults <25 years are similar to those previously identified in children and adolescents; older adults had few statistically significant risk factors.
摘要
背景
此前，我们使用囊性纤维化的流行病学研究（J Pediatr 2007;151:134-139）评估了儿童和青少年 FEV1 下降的危险因素；本研究评估了成年人的危险因素。
方法
使用混合模型回归评估了 18-24 岁和≥25 岁人群中，FEV1 在 3-5.5 年内下降的危险因素。
结果
18-24 岁组（n=2793）和≥25 岁组（n=1368）FEV1 年下降率（%预计值/年）分别为-1.92 和-1.45。在 18-24 岁组中，洋葱伯克霍尔德菌、胰酶使用、多药耐药铜绿假单胞菌、咳嗽、粘液型铜绿假单胞菌和女性性别预示着更大的下降；低基线 FEV1 和鼻窦炎预示着下降较小。在≥25 岁组中，只有胰酶使用预示着更大的下降；低基线 FEV1 和鼻窦炎预示着下降较小。
结论
18-24 岁以下成年人 FEV1 下降的危险因素与先前在儿童和青少年中确定的危险因素相似；老年患者的统计学显著危险因素较少。
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