Department of Biochemistry & Nutrition, CSIR, Central Food Technological Research Institute, Mysore, India.
Indian J Med Res. 2012 Mar;135(3):401-6.
BACKGROUND & OBJECTIVES: Cluster beans (Cyamopsis tetragonoloba) are rich source of soluble fibre content and are known for their cholesterol lowering effect. The beneficial anti-hypercholesterolaemic effect of whole dietary cluster beans as a source of dietary fibre was evaluated in high cholesterol diet induced hypercholesterolaemia in experimental rats.
Male Wistar rats (90-95 g) divided in six groups of 10 rats each were used. Freeze dried tender cluster beans were included at 12.5 and 25 per cent levels in the diet of animals maintained for 8 wk either on high (0.5%) cholesterol diet or basal control diet.
Significant anti-hypercholesterolaemic effect was seen in cluster bean fed animals, the decrease in serum cholesterol being particularly in the LDL associated fraction. There was also a beneficial increase in HDL associated cholesterol fraction. Hepatic lipid profile showed a significant decrease in both cholesterol and triglycerides as a result of feeding tender cluster beans along with high cholesterol diet.
INTERPRETATION & CONCLUSIONS: The present experimental results showed the beneficial hypocholesterolaemic and hypolipidimic influences dietary tender cluster beans in atherogenic situation. Studies in human need to be done to confirm the results.
兵豆富含可溶性膳食纤维，具有降低胆固醇的作用。本实验旨在研究兵豆作为膳食纤维来源对高胆固醇饮食诱导的实验性大鼠高脂血症的有益的抗高胆固醇作用。
雄性 Wistar 大鼠（90-95g）分为 6 组，每组 10 只。将冻干的嫩兵豆分别以 12.5%和 25%的水平添加到动物饮食中，连续喂养 8 周，其中一组给予高胆固醇（0.5%）饮食，另一组给予基础对照饮食。
兵豆喂养的动物表现出显著的抗高胆固醇作用，血清胆固醇的降低主要与 LDL 相关。同时，HDL 相关胆固醇也有有益的增加。肝脂质谱显示，由于同时给予高胆固醇饮食和嫩兵豆，胆固醇和甘油三酯均显著降低。
本实验结果表明，兵豆在动脉粥样硬化情况下具有有益的降胆固醇和降血脂作用。需要在人体中进行研究以证实这些结果。
