Department of Biochemistry and Nutrition, Central Food Technological Research Institute, CSIR, Mysore 570 020, India.
J Agric Food Chem. 2012 Aug 22;60(33):8155-62. doi: 10.1021/jf301211c. Epub 2012 Aug 13.
Soluble fiber-rich tender cluster bean pod (Cyamopsis tetragonoloba) (CB) and a combination of CB and capsaicin, a thermogenic spice compound, were evaluated for weight-reducing effect in high-fat-fed Wistar rats. Freeze-dried CB and capsaicin were included at 15 and 0.015%, respectively, in the high-fat (30%) diet for 8 weeks. Excretion of dietary fat, fat deposition in adipose, and activities of enzymes involved in lipolysis and lipogenesis were examined. CB and capsaicin additively decreased weight gain in high-fat-fed rats, without affecting feed intake. The antiobesity potential of CB was through impeding fat accumulation in adipose and enhancing fat excretion. Decrease in adipose triglyceride by the combination was higher than their individual effects and was accompanied by enhanced activity of hormone-sensitive lipase-facilitating mobilization of depot fat. Increased fecal excretion of triglycerides by the combination of CB and capsaicin was additive. Whereas the hypolipidemic effect of the combination was higher than their individual effects, the decrease in hepatic cholesterol and triglycerides produced by the combination was additve. Thus, dietary CB significantly checked weight gain and adverse changes in lipid profile in high-fat-fed condition amounting to a cardioprotective effect. These beneficial effects were potentiated by coadministration of capsaicin.
富含可溶性纤维的嫩兵豆荚（兵豆）和辣椒素（一种产热香料化合物）的混合物，在高脂肪喂养的 Wistar 大鼠中被评估其减肥效果。在高脂肪（30%）饮食中，分别将冻干的兵豆和辣椒素添加到 15%和 0.015%，为期 8 周。检测了饮食脂肪的排泄、脂肪在脂肪组织中的沉积以及参与脂肪分解和脂肪生成的酶的活性。兵豆和辣椒素可协同减少高脂肪喂养大鼠的体重增加，而不影响饲料摄入量。兵豆的抗肥胖潜力是通过阻止脂肪在脂肪组织中的积累和增强脂肪排泄来实现的。组合对脂肪组织三酸甘油脂的减少作用高于其各自的效果，并且伴随着激素敏感性脂肪酶活性的增强，促进了储存脂肪的动员。兵豆和辣椒素组合增加了粪便中三酸甘油脂的排泄，这种效果是累加的。虽然组合的降血脂效果高于各自的效果，但组合对肝脏胆固醇和三酸甘油脂的降低作用是累加的。因此，饮食中的兵豆可显著抑制高脂肪喂养条件下的体重增加和血脂谱的不利变化，从而产生心脏保护作用。辣椒素的共同给药增强了这些有益效果。
