Institute of Surface Engineering, Taiyuan University of Technology, 79 Yingze Road, Taiyuan 030024, PR China.
J Biosci Bioeng. 2012 Jul;114(1):1-8. doi: 10.1016/j.jbiosc.2012.02.024. Epub 2012 May 5.
As a type of 3D model, the technology of microencapsulation holds significant promise for tissue engineering and cell therapy due to its unique performance. The microenvironmental factors within microcapsules play an important role in influencing the behaviors of encapsulated cells. The aim of this review article is to give an overview on the construction of the microenvironmental factors, which include 3D space, physicochemical properties of alginate matrix, cell spheroids, nutritional status, and so on. Furthermore, we clarified the effect of microenvironmental factors on the behaviors of encapsulated cells and the methods about improving the microenvironment of microcapsules. This review will help to understand the interaction of the microenvironment and the encapsulated cells and lay a solid foundation for microcapsule-based cell therapy and tissue engineering.
作为一种 3D 模型，微胶囊化技术因其独特的性能，在组织工程和细胞治疗方面具有重要的应用前景。微胶囊内的微环境因素在影响被包裹细胞的行为方面起着重要作用。本文综述了微环境因素的构建，包括 3D 空间、海藻酸钠基质的理化性质、细胞球状体、营养状态等，同时阐明了微环境因素对被包裹细胞行为的影响以及改善微胶囊微环境的方法。本文的综述有助于理解微环境与被包裹细胞的相互作用，为基于微胶囊的细胞治疗和组织工程奠定了坚实的基础。
