Department of Applied Physics, Royal Institute of Technology, SE-10691, Stockholm, Sweden.
Lab Chip. 2012 May 8;12(11):2018-28. doi: 10.1039/c2lc40201g. Epub 2012 May 4.
Manipulation of biological cells by acoustic radiation forces is often motivated by its improved biocompatibility relative to alternative available methods. On the other hand, it is well known that acoustic exposure is capable of causing damage to tissue or cells, primarily due to heating or cavitation effects. Therefore, it is important to define safety guidelines for the design and operation of the utilized devices. This tutorial discusses the biocompatibility of devices designed for acoustic manipulation of mammalian cells, and different methods for quantifying the cell viability in such devices.
通过声辐射力对生物细胞进行操作通常是因为其相对于其他可用方法具有更好的生物相容性。另一方面，众所周知，声辐射有能力造成组织或细胞损伤，主要是由于热效应或空化效应。因此，为设计和操作所使用的设备定义安全指南是很重要的。本教程讨论了设计用于哺乳动物细胞声操控的设备的生物相容性，以及在这种设备中量化细胞活力的不同方法。
