Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto St., A300 Crabtree Hall, Pittsburgh, PA 15260, USA.
J Dent Res. 2012 Jul;91(7):637-41. doi: 10.1177/0022034512446968. Epub 2012 May 4.
The genomic era of biomedical research has given rise to the genome-wide association study (GWAS) approach, which attempts to discover novel genes affecting an outcome by testing a large number (i.e., hundreds of thousands to millions) of genetic variants for association. This article discusses the issues surrounding the GWAS approach with emphasis on the prospects and challenges relevant to the oral health research community.
生物医学研究的基因组时代催生了全基因组关联研究（GWAS）方法，该方法试图通过检测大量（即数十万到数百万）遗传变异与结果的关联来发现影响结果的新基因。本文讨论了围绕 GWAS 方法的问题，重点介绍了与口腔健康研究界相关的前景和挑战。
