Optometry Research Group, Department of Optics, University of Valencia, Dr. Moliner, 50, 46100 Burjassot, Valencia, Spain.
Graefes Arch Clin Exp Ophthalmol. 2013 Jan;251(1):331-40. doi: 10.1007/s00417-012-2041-5. Epub 2012 May 6.
To evaluate visual, optical, and quality of life (QoL) outcomes and intercorrelations after bilateral implantation of posterior chamber phakic intraocular lenses.
Twenty eyes with high to moderate myopia of 10 patients that underwent PRL implantation (Phakic Refractive Lens, Carl Zeiss Meditec AG) were examined. Refraction, visual acuity, photopic and low mesopic contrast sensitivity (CS) with and without glare, ocular aberrations, as well as QoL outcomes (National Eye Institute Refractive Error Quality of Life Instrument-42, NEI RQL-42) were evaluated at 12 months postoperatively.
Significant improvement in uncorrected (UDVA) and best-corrected distance (CDVA) visual acuities were found postoperatively (p < 0.01), with significant reduction in spherical equivalent (p < 0.01). Low mesopic CS without glare was significantly better than measurements with glare for 1.5, 3, and 6 cycles/degree (p < 0.01). No significant correlations between higher order root mean square (RMS) with CDVA (r = -0.26, p = 0.27) and CS (r ≤ 0.45, p ≥ 0.05) were found. Postoperative binocular photopic CS for 12 cycles/degree and 18 cycles/degree correlated significantly with several RQL-42 scales. Glare index correlated significantly with CS measures and scotopic pupil size (r = -0.551, p = 0.04), but not with higher order RMS (r = -0.02, p = 0.94). Postoperative higher order RMS, postoperative primary coma and postoperative spherical aberration was significant higher for 5-mm pupil diameter (p < 0.01) compared with controls.
Correction of moderate to high myopia by means of PRL implantation had a positive impact on CS and QoL. The aberrometric increase induced by the surgery does not seem to limit CS and QoL. However, perception of glare is still a relevant disturbance in some cases possibly related to the limitation of the optical zone of the PRL.
评估双眼植入后房型有晶状体眼人工晶状体后的视觉、光学和生活质量（QoL）结果及相关性。
对 10 例 20 只眼高度至中度近视患者行 PRL 植入术（Phakic Refractive Lens，Carl Zeiss Meditec AG），术后 12 个月时检查屈光度、视力、明视和低中空间对比敏感度（CS）、眩光、眼像差以及生活质量（国家眼科研究所屈光不正生活质量量表-42，NEI RQL-42）。
术后未矫正（UDVA）和最佳矫正（CDVA）视力显著提高（p < 0.01），球镜等效显著降低（p < 0.01）。低中空间无眩光 CS 明显优于有眩光 CS（p < 0.01），1.5、3 和 6 周期/度。高阶均方根（RMS）与 CDVA（r = -0.26，p = 0.27）和 CS（r ≤ 0.45，p ≥ 0.05）之间无显著相关性。双眼明视 12 周期/度和 18 周期/度 CS 与多项 RQL-42 量表显著相关。眩光指数与 CS 测量值和暗瞳大小显著相关（r = -0.551，p = 0.04），但与高阶 RMS 无显著相关性（r = -0.02，p = 0.94）。与对照组相比，5mm 瞳孔直径时术后高阶 RMS、术后初级彗差和术后球差显著增加（p < 0.01）。
通过 PRL 植入术矫正中高度近视对 CS 和 QoL 有积极影响。手术引起的像差增加似乎不会限制 CS 和 QoL。然而，在某些情况下，眩光的感知仍然是一个相关的干扰因素，可能与 PRL 的光区限制有关。
