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本文引用的文献

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Directed chromosomal integration and expression of the reporter gene gusA3 in Lactobacillus acidophilus NCFM.嗜酸乳杆菌 NCFM 中转录报告基因 gusA3 的定向染色体整合和表达。
Appl Environ Microbiol. 2011 Oct;77(20):7365-71. doi: 10.1128/AEM.06028-11. Epub 2011 Aug 26.
2
Analysis of the human intestinal epithelial cell transcriptional response to Lactobacillus acidophilus, Lactobacillus salivarius, Bifidobacterium lactis and Escherichia coli.分析嗜酸乳杆菌、唾液乳杆菌、双歧杆菌和大肠杆菌对人肠道上皮细胞转录反应的影响。
Benef Microbes. 2010 Sep;1(3):283-95. doi: 10.3920/BM2010.0003.
3
Dissimilar properties of two recombinant Lactobacillus acidophilus strains displaying Salmonella FliC with different anchoring motifs.两种具有不同锚定基序的重组嗜酸乳杆菌菌株展示沙门氏菌 FliC 的不同特性。
Appl Environ Microbiol. 2011 Sep;77(18):6587-96. doi: 10.1128/AEM.05153-11. Epub 2011 Jul 22.
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Crosstalk in NF-κB signaling pathways.NF-κB 信号通路中的串扰。
Nat Immunol. 2011 Jul 19;12(8):695-708. doi: 10.1038/ni.2065.
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Probiotics for prevention of antibiotic-associated diarrhea and Clostridium difficile-associated disease in hospitalized adults--a meta-analysis.益生菌用于预防住院成人抗生素相关性腹泻及艰难梭菌相关性疾病——一项荟萃分析
J Am Acad Nurse Pract. 2011 Jun;23(6):269-74. doi: 10.1111/j.1745-7599.2011.00617.x. Epub 2011 Apr 27.
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Construction of vectors for inducible and constitutive gene expression in Lactobacillus.构建诱导型和组成型基因表达载体在乳杆菌中的应用。
Microb Biotechnol. 2011 May;4(3):357-67. doi: 10.1111/j.1751-7915.2010.00200.x. Epub 2010 Sep 1.
7
Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation.植物乳杆菌 MB452 通过增加参与紧密连接形成的基因的表达水平来增强肠道屏障功能。
BMC Microbiol. 2010 Dec 9;10:316. doi: 10.1186/1471-2180-10-316.
8
Functional and phenotypic characterization of a protein from Lactobacillus acidophilus involved in cell morphology, stress tolerance and adherence to intestinal cells.嗜酸乳杆菌中一种参与细胞形态、应激耐受和黏附肠细胞的蛋白质的功能和表型特征。
Microbiology (Reading). 2010 Nov;156(Pt 11):3360-3367. doi: 10.1099/mic.0.043158-0. Epub 2010 Sep 9.
9
Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways.人类黏膜体内转录组对三种乳杆菌的反应表明益生菌可能如何调节人体细胞途径。
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10
Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens.益生菌细菌表面分子的宿主相互作用：与共生菌和病原体的比较。
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嗜酸乳杆菌暴露时间对人肠上皮细胞基因表达的影响。

Influence of exposure time on gene expression by human intestinal epithelial cells exposed to Lactobacillus acidophilus.

机构信息

Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, NC, USA.

出版信息

Appl Environ Microbiol. 2012 Jul;78(14):5028-32. doi: 10.1128/AEM.00504-12. Epub 2012 May 4.

DOI:10.1128/AEM.00504-12
PMID:22562992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3416389/
Abstract

Analysis of global temporal gene expression by human intestinal cells when exposed to Lactobacillus acidophilus revealed induction of immune-related pathways and NF-κB target genes after a 1-h exposure, compared to a 4- or 8-h exposure. Additionally, an L. acidophilus derivative expressing covalently bound flagellin resulted in increased induction of il8, cxc1, and cxcl2 compared to the parent L. acidophilus.

摘要

分析人类肠道细胞暴露于嗜酸乳杆菌时的全球时空调控基因表达，与暴露 4 或 8 小时相比，1 小时暴露后诱导免疫相关途径和 NF-κB 靶基因。此外，与亲本嗜酸乳杆菌相比，表达共价结合鞭毛蛋白的嗜酸乳杆菌衍生物导致 il8、cxc1 和 cxcl2 的诱导增加。