NF-κB 信号通路中的串扰。
Crosstalk in NF-κB signaling pathways.
机构信息
Department of Microbiology & Immunology, Columbia University, College of Physicians & Surgeons, New York, New York, USA.
出版信息
Nat Immunol. 2011 Jul 19;12(8):695-708. doi: 10.1038/ni.2065.
NF-κB transcription factors are critical regulators of immunity, stress responses, apoptosis and differentiation. A variety of stimuli coalesce on NF-κB activation, which can in turn mediate varied transcriptional programs. Consequently, NF-κB-dependent transcription is not only tightly controlled by positive and negative regulatory mechanisms but also closely coordinated with other signaling pathways. This intricate crosstalk is crucial to shaping the diverse biological functions of NF-κB into cell type- and context-specific responses.
NF-κB 转录因子是免疫、应激反应、细胞凋亡和分化的关键调节因子。各种刺激因素集中在 NF-κB 的激活上，而 NF-κB 的激活又可以介导不同的转录程序。因此，NF-κB 依赖性转录不仅受到正调控和负调控机制的严格控制，而且还与其他信号通路密切协调。这种复杂的串扰对于将 NF-κB 的多种生物学功能塑造为细胞类型和特定环境的特异性反应至关重要。
Zotero 插件