Centre of Microbial and Plant Genetics, K.U.Leuven, Kasteelpark Arenberg 20, bus 2460, B-3001 Leuven, Belgium.
Nat Rev Microbiol. 2010 Mar;8(3):171-84. doi: 10.1038/nrmicro2297.
How can probiotic bacteria transduce their health benefits to the host? Bacterial cell surface macromolecules are key factors in this beneficial microorganism-host crosstalk, as they can interact with host pattern recognition receptors (PRRs) of the gastrointestinal mucosa. In this Review, we highlight the documented signalling interactions of the surface molecules of probiotic bacteria (such as long surface appendages, polysaccharides and lipoteichoic acids) with PRRs. Research on host-probiotic interactions can benefit from well-documented host-microorganism studies that span the spectrum from pathogenicity to mutualism. Distinctions and parallels are therefore drawn with the interactions of similar molecules that are presented by gastrointestinal commensals and pathogens.
益生菌细菌如何将其健康益处传递给宿主？细菌细胞表面大分子是这种有益微生物-宿主串扰的关键因素，因为它们可以与胃肠道黏膜的宿主模式识别受体 (PRR) 相互作用。在这篇综述中，我们强调了益生菌细菌表面分子（如长表面附属物、多糖和脂磷壁酸）与 PRR 之间已记录的信号相互作用。对宿主-益生菌相互作用的研究可以受益于从致病性到共生性的跨度都有详细记录的宿主-微生物研究。因此，与胃肠道共生菌和病原体呈现的类似分子的相互作用进行了区分和比较。
