de Oliveira Rita Machado, Sarkander Jana, Kazantsev Aleksey G, Outeiro Tiago Fleming
Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular Lisboa, Portugal.
Front Pharmacol. 2012 May 3;3:82. doi: 10.3389/fphar.2012.00082. eCollection 2012.
Sirtuin proteins are conserved regulators of aging that have recently emerged as important modifiers of several diseases which commonly occur later in life such as cancer, diabetes, cardiovascular, and neurodegenerative diseases. In mammals, there are seven sirtuins (SIRT1-7), which display diversity in subcellular localization and function. SIRT1 has received much of attention due to its possible impact on longevity, while important biological and therapeutic roles of other sirtuins have been underestimated and just recently recognized. Here we focus on SIRT2, a member of the sirtuin family, and discuss its role in cellular and tissue-specific functions. This review summarizes the main scientific advances on SIRT2 protein biology and explores its potential as a therapeutic target for treatment of age-related disorders.
沉默调节蛋白是衰老过程中保守的调节因子，最近已成为几种常见于生命后期的疾病（如癌症、糖尿病、心血管疾病和神经退行性疾病）的重要调节因子。在哺乳动物中，有七种沉默调节蛋白（SIRT1-7），它们在亚细胞定位和功能上表现出多样性。SIRT1因其对寿命的可能影响而备受关注，而其他沉默调节蛋白的重要生物学和治疗作用则一直被低估，直到最近才被认识到。在这里，我们聚焦于沉默调节蛋白家族成员SIRT2，并讨论其在细胞和组织特异性功能中的作用。本综述总结了SIRT2蛋白质生物学的主要科学进展，并探讨了其作为治疗与年龄相关疾病的治疗靶点的潜力。
