Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
J Org Chem. 2012 Jun 1;77(11):5149-54. doi: 10.1021/jo300562j. Epub 2012 May 11.
A novel microwave-assisted approach for the one-pot Cu(I)-catalyzed A(3)-coupling/decarboxylative coupling (PA(2)-coupling) of a propiolic acid, an aldehyde, and an amine, resulting in the formation of diversely substituted 1,4-diamino-2-butynes,is described. It is noteworthy that this new multicomponent coupling provides an efficient access to introduce alkyl and aryl group at the 1,4-position of the 1,4-diamino-2-butynes.
一种新颖的微波辅助一锅法，用于实现丙炔酸、醛和胺的 Cu(I)-催化 A(3)-偶联/脱羧偶联（PA(2)-偶联），生成各种取代的 1,4-二氨基-2-丁炔。值得注意的是，这种新的多组分偶联提供了一种有效的方法，可在 1,4-二氨基-2-丁炔的 1,4-位引入烷基和芳基。
