氧化还原A反应。
The Redox-A Reaction.
作者信息
Seidel Daniel
出版信息
Org Chem Front. 2014 Jun 1;1(4):426-429. doi: 10.1039/C4QO00022F.
Abstract
This Highlight details the recent emergence of a new type of A reaction (three-component condensation of an amine, an aldehyde and an alkyne). In contrast to the classic A coupling process, the redox-A reaction incorporates an iminium isomerization step and leads to amine α-alkynylation. The overall transformation is redox-neutral by virtue of a combined reductive -alkylation/oxidative C-H bond functionalization.
摘要
本亮点介绍了一种新型A反应（胺、醛和炔烃的三组分缩合反应）的最新出现情况。与经典的A偶联过程不同，氧化还原-A反应包含一个亚胺鎓异构化步骤，并导致胺的α-炔基化。通过还原烷基化/氧化C-H键官能化的组合，整个转化过程是氧化还原中性的。
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