Silverdal Jonas, Mourtzinis Georgios, Stener-Victorin Elisabet, Mannheimer Clas, Manhem Karin
Department of Internal Medicine and Geriatrics, Sahlgrenska University Hospital/Östra, SE-416 85 Gothenburg, Sweden.
Blood Press. 2012 Oct;21(5):306-10. doi: 10.3109/08037051.2012.680737. Epub 2012 May 8.
Hypertension is a major risk factor for vascular disease, yet blood pressure (BP) control is unsatisfactory low, partly due to side-effects. Transcutaneous electrical nerve stimulation (TENS) is well tolerated and studies have demonstrated BP reduction. In this study, we compared the BP lowering effect of 2.5 mg felodipin once daily with 30 min of bidaily low-frequency TENS in 32 adult hypertensive subjects (mean office BP 152.7/90.0 mmHg) in a randomized, crossover design. Office BP and 24-h ambulatory BP monitoring (ABPM) were performed at baseline and at the end of each 4-week treatment and washout period. Felodipin reduced office BP by 10/6 mmHg (p <0.001 respectively) and after washout BP rose to a level still significantly lower than at baseline. TENS reduced office BP by 5/1.5 mmHg (p <0.01, ns). After TENS washout, BP was further reduced and significantly lower than at baseline, but at levels similar to BP after felodipin washout and therefore reasonably caused by factors other than the treatment per se. ABPM revealed a significant systolic reduction of 3 mmHg by felodipin, but no significant changes were noted after TENS. We conclude that our study does not present any solid evidence of BP reduction of TENS.
高血压是血管疾病的主要危险因素，但血压（BP）控制水平却低得不尽人意，部分原因是副作用。经皮电刺激神经疗法（TENS）耐受性良好，且研究已证实其有降低血压的作用。在本研究中，我们采用随机交叉设计，对32名成年高血压患者（平均诊室血压为152.7/90.0 mmHg）进行了比较，一组每天服用一次2.5 mg非洛地平，另一组每天进行两次每次30分钟的低频TENS治疗。在基线以及每4周治疗期和洗脱期结束时，均进行诊室血压测量和24小时动态血压监测（ABPM）。非洛地平使诊室血压降低了10/6 mmHg（p分别<0.001），洗脱期后血压虽有所回升，但仍显著低于基线水平。TENS使诊室血压降低了5/1.5 mmHg（p<0.01，无统计学意义）。TENS洗脱期后，血压进一步下降且显著低于基线水平，但与非洛地平洗脱期后的血压水平相似，因此可能是由治疗本身以外的因素合理导致的。ABPM显示非洛地平使收缩压显著降低了3 mmHg，但TENS治疗后未观察到显著变化。我们得出结论，本研究没有提供任何确凿证据表明TENS能降低血压。
