精子 DNA 和 RNA 异常与生育能力正常和少精弱精症吸烟男性。

Sperm DNA and RNA abnormalities in fertile and oligoasthenoteratozoospermic smokers.

机构信息

Department of Dermatology and Andrology, Faculty of Medicine, Menoufiya University, Menoufiya, Egypt.

出版信息

Andrologia. 2013 Feb;45(1):35-9. doi: 10.1111/j.1439-0272.2012.01305.x. Epub 2012 May 8.

DOI:10.1111/j.1439-0272.2012.01305.x

Abstract

This study aimed to assess sperm DNA and RNA abnormalities in fertile and oligoasthenoteratozoospermic (OAT) smokers. In all, 140 subjects were included and classified into fertile nonsmokers, fertile smokers, OAT nonsmokers and OAT smokers. They were subjected to history taking, clinical examination, semen analysis, assessment of sperm DNA and RNA abnormalities. The results showed that an increased percentage of abnormal sperm DNA and RNA was demonstrated in fertile smokers compared with fertile nonsmokers and in OAT smokers compared with OAT nonsmokers. Increased percentage of severe, moderate sperm DNA and RNA damage was demonstrated in fertile heavy smokers compared with fertile light smokers and in OAT heavy smokers compared with OAT light smokers. It is concluded that smoking has a negative impact on sperm DNA and RNA abnormalities that is accentuated in heavy smokers compared with light smokers.

摘要

本研究旨在评估生育能力正常和少精弱精症（OAT）吸烟男性的精子 DNA 和 RNA 异常。共纳入 140 名受试者，分为生育能力正常不吸烟者、生育能力正常吸烟者、OAT 不吸烟者和 OAT 吸烟者。对他们进行了病史采集、临床检查、精液分析、精子 DNA 和 RNA 异常评估。结果显示，与生育能力正常不吸烟者相比，生育能力正常吸烟者的精子 DNA 和 RNA 异常比例增加；与 OAT 不吸烟者相比，OAT 吸烟者的精子 DNA 和 RNA 异常比例增加。与生育能力正常轻吸烟者相比，生育能力正常重度吸烟者的严重、中度精子 DNA 和 RNA 损伤比例增加；与 OAT 轻吸烟者相比，OAT 重度吸烟者的严重、中度精子 DNA 和 RNA 损伤比例增加。结论是，吸烟对精子 DNA 和 RNA 异常有负面影响，重度吸烟者比轻度吸烟者更为明显。