某些糖蛋白合成抑制剂对水泡性口炎病毒诱导的细胞融合的影响。

Effect of certain inhibitors of glycoprotein synthesis on cell fusion induced by vesicular stomatitis virus.

作者信息

Takehara M

出版信息

Microbiol Immunol. 1979;23(3):167-76. doi: 10.1111/j.1348-0421.1979.tb00453.x.

DOI:10.1111/j.1348-0421.1979.tb00453.x

Abstract

The effect of certain metabolic inhibitors on the fusion of BHK-21 cells induced by vesicular stomatitis virus (VSV) was studied. The polykaryocyte formation in infected cells and virus growth were inhibited by 2-deoxy-D-glucose and D-glucosamine. Host-cell proteins synthesis was suppressed profoundly in both BHK-21-KB and B cells infected with VSV. On the other hand, glycoprotein synthesis was significantly enhanced during the polykaryocyte formation in BHK-21-KB cells, while it was suppressed in BHK-21-B cells which were not sensitive to cell fusion by VSV.

摘要

研究了某些代谢抑制剂对水泡性口炎病毒（VSV）诱导的BHK - 21细胞融合的影响。2 - 脱氧 - D - 葡萄糖和D - 葡糖胺可抑制感染细胞中的多核细胞形成和病毒生长。在感染VSV的BHK - 21 - KB和B细胞中，宿主细胞蛋白质合成均受到显著抑制。另一方面，在BHK - 21 - KB细胞多核细胞形成过程中，糖蛋白合成显著增强，而在对VSV诱导的细胞融合不敏感的BHK - 21 - B细胞中，糖蛋白合成受到抑制。