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改良悬雍垂腭咽成形术联合咽侧成形术治疗阻塞性睡眠呼吸暂停后计算机辅助定量上气道分析:前瞻性病例对照研究。

Computer-assisted quantitative upper airway analysis following modified uvulopalatal flap and lateral pharyngoplasty for obstructive sleep apnoea: a prospective case-controlled study.

机构信息

Department of Otolaryngology, Changi General Hospital, 2 Simei Street 3, Singapore.

出版信息

Clin Otolaryngol. 2012 Jun;37(3):188-96. doi: 10.1111/j.1749-4486.2012.02491.x.

Abstract

OBJECTIVES

The study aims to perform static and dynamic quantitative assessment of the anatomical changes of the upper airway before and after modified uvulopalatal flap and lateral pharyngoplasty and comparison of the improvement in airway dimensions, collapsibility and extent of normalisation to that of control patients.

DESIGN

Prospective case-controlled study.

SETTING

Computer-assisted quantitative measurement is used to compare upper airway parameters before and after modified uvulopalatal flap and lateral pharyngoplasty in patients with obstructive sleep apnoea (OSA).

PARTICIPANTS

Patients with obstructive sleep apnoea diagnosed on sleep study and failed positive airway pressure therapy.

MAIN OUTCOME MEASURES

Sleep study results, upper airway parameters and symptom score following surgery and its comparison to normal patients to assess the degree and extent of normalisation.

RESULTS

Thirty-five study and 32 control subjects were recruited and completed the study. All the retropalatal airway dimensions like area, transverse diameter, longitudinal diameter and collapsibility showed statistically significant improvement following surgery. The success rate of this surgery is 43% (15 of 35) overall, 58% (14 of 24) for patients with isolated palatal obstruction and only 9% (1 of 11) for patients with multi-level obstruction. Comparing obstructive sleep apnoea to the control subjects, there are obvious and logical differences in their biostatistics, sleep study parameters and airway dimensions. The postoperative obstructive sleep apnoea retropalatal longitudinal diameter has a higher tendency of normalising to be comparable to those of control patients.

CONCLUSIONS

Modified uvulopalatal flap and lateral pharyngoplasty is an effective surgical technique for the treatment of obstructive sleep apnoea. The surgery increases the resting retropalatal dimensions and reduces the retropalatal collapsibility.

摘要

目的

本研究旨在对改良悬雍垂腭咽成形术和侧咽成形术前后上气道的解剖变化进行静态和动态定量评估,并将气道尺寸、塌陷程度和正常化程度的改善与对照组患者进行比较。

设计

前瞻性病例对照研究。

地点

计算机辅助定量测量用于比较阻塞性睡眠呼吸暂停(OSA)患者改良悬雍垂腭咽成形术和侧咽成形术前后上气道参数。

参与者

睡眠研究诊断为阻塞性睡眠呼吸暂停且正压通气治疗失败的患者。

主要观察指标

睡眠研究结果、手术后上气道参数和症状评分,并与正常患者进行比较,以评估正常化程度和范围。

结果

共纳入 35 例研究和 32 例对照患者,均完成了研究。所有后咽气道尺寸,如面积、横径、纵径和塌陷度,术后均有统计学意义的改善。该手术的总成功率为 43%(35 例中有 15 例),单纯腭后阻塞患者为 58%(24 例中有 14 例),多水平阻塞患者仅为 9%(11 例中有 1 例)。将阻塞性睡眠呼吸暂停与对照组进行比较,在统计学、睡眠研究参数和气道尺寸方面存在明显的差异。术后阻塞性睡眠呼吸暂停后咽纵径有更高的正常化趋势,与对照组患者相当。

结论

改良悬雍垂腭咽成形术和侧咽成形术是治疗阻塞性睡眠呼吸暂停的有效手术方法。手术增加了静止时的后咽尺寸,降低了后咽塌陷度。

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