Department of Occupational Health, Third Military Medical University, Chongqing 400038, China.
Physiol Behav. 2012 Jul 16;106(5):631-7. doi: 10.1016/j.physbeh.2012.04.019. Epub 2012 Apr 28.
Extensive evidence indicates that glucose administration attenuates memory deficits in rodents and humans, and cognitive impairment has been associated with reduced glucose metabolism and uptake in certain brain regions including the hippocampus. In the present study, we investigated whether glucose treatment attenuated memory deficits caused by chronic low-power-density microwave (MW) exposure, and the effect of MW exposure on hippocampal glucose uptake. We exposed Wistar rats to 2.45 GHz pulsed MW irradiation at a power density of 1 mW/cm(2) for 3 h/day, for up to 30 days. MW exposure induced spatial learning and memory impairments in rats. Hippocampal glucose uptake was also reduced by MW exposure in the absence or presence of insulin, but the levels of blood glucose and insulin were not affected. However, these spatial memory deficits were reversed by systemic glucose treatment. Our results indicate that glucose administration attenuates the spatial memory deficits induced by chronic low-power-density MW exposure, and reduced hippocampal glucose uptake may be associated with cognitive impairment caused by MW exposure.
大量证据表明，葡萄糖给药可减轻啮齿动物和人类的记忆障碍，并且认知障碍与某些脑区（包括海马体）的葡萄糖代谢和摄取减少有关。在本研究中，我们研究了葡萄糖处理是否可以减轻由慢性低功率密度微波（MW）暴露引起的记忆缺陷，以及 MW 暴露对海马体葡萄糖摄取的影响。我们将 Wistar 大鼠暴露于 2.45GHz 脉冲 MW 辐射下，功率密度为 1mW/cm2，每天 3 小时，长达 30 天。MW 暴露导致大鼠出现空间学习和记忆障碍。在没有或存在胰岛素的情况下，MW 暴露也会降低海马体的葡萄糖摄取，但血糖和胰岛素水平不受影响。然而，这些空间记忆缺陷可通过全身葡萄糖处理逆转。我们的结果表明，葡萄糖给药可减轻慢性低功率密度 MW 暴露引起的空间记忆缺陷，并且海马体葡萄糖摄取减少可能与 MW 暴露引起的认知障碍有关。
