Faculty of Sciences of Bizerte, Laboratory of Integrative Physiology, University of Carthage, 7021, Jarzouna, Tunisia.
Higher Institute of Applied Biological Sciences of Tunis, University of Tunis El Manar, 9, Rue Zouhair Essafi, 1006, Tunis, Tunisia.
Metab Brain Dis. 2017 Oct;32(5):1459-1469. doi: 10.1007/s11011-017-0016-2. Epub 2017 Apr 27.
Today, due to technology development and aversive events of daily life, Human exposure to both radiofrequency and stress is unavoidable. This study investigated the co-exposure to repeated restraint stress and WiFi signal on cognitive function and oxidative stress in brain of male rats. Animals were divided into four groups: Control, WiFi-exposed, restrained and both WiFi-exposed and restrained groups. Each of WiFi exposure and restraint stress occurred 2 h (h)/day during 20 days. Subsequently, various tests were carried out for each group, such as anxiety in elevated plus maze, spatial learning abilities in the water maze, cerebral oxidative stress response and cholinesterase activity in brain and serum. Results showed that WiFi exposure and restraint stress, alone and especially if combined, induced an anxiety-like behavior without impairing spatial learning and memory abilities in rats. At cerebral level, we found an oxidative stress response triggered by WiFi and restraint, per se and especially when combined as well as WiFi-induced increase in acetylcholinesterase activity. Our results reveal that there is an impact of WiFi signal and restraint stress on the brain and cognitive processes especially in elevated plus maze task. In contrast, there are no synergistic effects between WiFi signal and restraint stress on the brain.
如今，由于科技的发展和日常生活中的种种压力事件，人类不可避免地会同时接触到射频和压力。本研究探讨了重复束缚应激和 WiFi 信号共同暴露对雄性大鼠认知功能和大脑氧化应激的影响。动物被分为四组：对照组、WiFi 暴露组、束缚组和 WiFi 暴露加束缚组。WiFi 暴露和束缚应激每天各进行 2 小时（h），持续 20 天。随后，对每组动物进行了各种测试，如高架十字迷宫中的焦虑测试、水迷宫中的空间学习能力测试、大脑氧化应激反应和脑及血清中的乙酰胆碱酯酶活性测试。结果表明，WiFi 暴露和束缚应激单独或联合暴露会引起类似焦虑的行为，而不会损害大鼠的空间学习和记忆能力。在大脑水平上，我们发现 WiFi 和束缚应激本身以及联合暴露会引起氧化应激反应，同时 WiFi 还会引起乙酰胆碱酯酶活性的增加。我们的结果表明，WiFi 信号和束缚应激会对大脑和认知过程产生影响，尤其是在高架十字迷宫任务中。然而，WiFi 信号和束缚应激之间没有协同作用。
