Gagnon R, Hunse C, Carmichael L, Patrick J
Department of Obstetrics and Gynecology, Lawson Research Institute, University of Western Ontario, London, Canada.
Am J Obstet Gynecol. 1989 Jan;160(1):160-5. doi: 10.1016/0002-9378(89)90111-7.
Seven pregnant women with early-onset (less than 32 weeks' gestation) intrauterine growth retardation were studied to examine fetal heart rate and fetal activity patterns after vibratory acoustic stimulation. All studies were done between 26 and 32 weeks' gestation. All fetuses but one were not acidotic at birth. There was a reduced time during which accelerations (50% less), long-term fetal heart rate variability (25% less), and body movements (60% less) occurred in small-for-gestational-age fetuses compared with these times in age-matched normally grown fetuses. Fetal heart rate and fetal activity patterns were not significantly altered after stimulation with the electronic artificial larynx. We hypothesized that severe, early-onset (less than 32 weeks' gestation), chronic nutritional deprivation of human fetuses is associated with a delay in the functional maturation of fetal sensory receptors.
对7例早发型（妊娠小于32周）宫内生长受限的孕妇进行了研究，以检测振动声刺激后的胎儿心率和胎儿活动模式。所有研究均在妊娠26至32周之间进行。除1例胎儿外，其他所有胎儿出生时均未发生酸中毒。与年龄匹配的正常生长胎儿相比，小于胎龄儿出现加速（减少50%）、长期胎儿心率变异性（减少25%）和身体活动（减少60%）的时间有所缩短。使用电子人工喉刺激后，胎儿心率和胎儿活动模式未发生显著改变。我们推测，人类胎儿严重的早发型（妊娠小于32周）慢性营养剥夺与胎儿感觉受体功能成熟延迟有关。
