Department of Dermatology and Allergology, University of Szeged, H-6720 Szeged, Hungary.
Acta Derm Venereol. 2012 Nov;92(6):648-51. doi: 10.2340/00015555-1361.
Gorlin-Goltz syndrome is a rare multisystemic disease, characterized by numerous basal cell carcinomas. The ideal approach for patients with the syndrome would be a treatment with a high cure rate, minimal scarring, short healing time and mild side-effects. Electrochemo-therapy is a novel therapeutic option that ablates tumours with electrical current and simultaneously administered anticancer drugs. Three patients with Gorlin-Goltz syndrome were treated with electrochemotherapy using intravenous bleomycin. Clinical response was obtained in 98 (99%) of the lesions, 86 (87%) of them showed complete response. In 2 tumours, regression was confirmed with histological examination. Long-term cosmetic results were excellent. We consider electrochemotherapy to be an additional tool in the therapeutic armamentarium for Gorlin-Goltz syndrome, and suggest using it as early as possible in selected patients to avoid disfiguring scarring.
戈尔丁-戈特综合征是一种罕见的多系统疾病，其特征为多发性基底细胞癌。对于该综合征患者，理想的治疗方法是一种治愈率高、瘢痕最小、愈合时间短、副作用轻微的治疗方法。电化疗是一种通过电流和同时给予抗癌药物来消融肿瘤的新型治疗选择。使用静脉注射博来霉素对 3 名戈尔丁-戈特综合征患者进行了电化疗治疗。98%（99%）的病变获得了临床反应，其中 86%（87%）的病变完全缓解。在 2 个肿瘤中，通过组织学检查证实了消退。长期美容效果极佳。我们认为电化疗是戈尔丁-戈特综合征治疗武器库中的一种附加工具，并建议在有选择的患者中尽早使用，以避免毁容性瘢痕形成。
