一种不对称二聚体作为阿尔茨海默病淀粉样β纤维的基本亚基。 - Suppr

An asymmetric dimer as the basic subunit in Alzheimer's disease amyloid β fibrils.

作者信息

Lopez del Amo Juan Miguel, Schmidt Matthias, Fink Uwe, Dasari Muralidar, Fändrich Marcus, Reif Bernd

机构信息

Helmholtz-Zentrum München (HMGU), Deutsches Forschungszentrum für Gesundheit und Umwelt, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.

出版信息

Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6136-9. doi: 10.1002/anie.201200965. Epub 2012 May 8.

DOI:10.1002/anie.201200965

PMID:22565601

Abstract

摘要

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An asymmetric dimer as the basic subunit in Alzheimer's disease amyloid β fibrils.一种不对称二聚体作为阿尔茨海默病淀粉样β纤维的基本亚基。

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Structures and thermodynamics of Alzheimer's amyloid-beta Abeta(16-35) monomer and dimer by replica exchange molecular dynamics simulations: implication for full-length Abeta fibrillation.通过副本交换分子动力学模拟研究阿尔茨海默病淀粉样β蛋白Aβ(16 - 35)单体和二聚体的结构与热力学：对全长Aβ纤维化的启示

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Assembling amyloid fibrils from designed structures containing a significant amyloid beta-peptide fragment.从含有重要淀粉样β肽片段的设计结构中组装淀粉样纤维。

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Energy landscapes of the monomer and dimer of the Alzheimer's peptide Abeta(1-28).阿尔茨海默病肽β淀粉样蛋白（1-28）单体和二聚体的能量景观

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Fibrils with parallel in-register structure constitute a major class of amyloid fibrils: molecular insights from electron paramagnetic resonance spectroscopy.具有平行共线结构的原纤维构成了淀粉样原纤维的一大类：来自电子顺磁共振波谱的分子见解。

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Solid-state NMR spectroscopic investigation of Aβ protofibrils: implication of a β-sheet remodeling upon maturation into terminal amyloid fibrils.Aβ原纤维的固态核磁共振光谱研究：β-折叠重塑对成熟为终末淀粉样纤维的影响

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Supramolecular structure in full-length Alzheimer's beta-amyloid fibrils: evidence for a parallel beta-sheet organization from solid-state nuclear magnetic resonance.全长阿尔茨海默病β-淀粉样蛋白原纤维中的超分子结构：来自固态核磁共振的平行β-折叠结构组织的证据

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Mutations alter the geometry and mechanical properties of Alzheimer's Aβ(1-40) amyloid fibrils.突变改变了阿尔茨海默氏症 Aβ(1-40)淀粉样纤维的几何形状和机械性能。

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Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of beta-sheets in Alzheimer's beta-amyloid fibrils.多量子固态核磁共振表明，阿尔茨海默病β-淀粉样蛋白原纤维中的β-折叠呈平行而非反平行排列。

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Amyloid fibril dynamics revealed by combined hydrogen/deuterium exchange and nuclear magnetic resonance.通过氢/氘交换与核磁共振联用揭示的淀粉样纤维动力学

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An asymmetric dimer as the basic subunit in Alzheimer's disease amyloid β fibrils.

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