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Multi-timescale conformational dynamics of the SH3 domain of CD2-associated protein using NMR spectroscopy and accelerated molecular dynamics.

作者信息

Salmon Loïc, Pierce Levi, Grimm Alexander, Ortega Roldan Jose-Luis, Mollica Luca, Jensen Malene Ringkjøbing, van Nuland Nico, Markwick Phineus R L, McCammon J Andrew, Blackledge Martin

机构信息

Protein Dynamics and Flexibility, Institut de Biologie Structurale Jean-Pierre Ebel, CNRS-CEA-UJF, UMR 5075, 41 rue Jules Horowitz, 38027 Grenoble Cedex, France.

出版信息

Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6103-6. doi: 10.1002/anie.201202026. Epub 2012 May 8.

DOI:10.1002/anie.201202026
PMID:22565613
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3541011/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cde/3793234/893acca509ae/anie0051-6103-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cde/3793234/1b4a53f2ba25/anie0051-6103-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cde/3793234/ef9072c728b2/anie0051-6103-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cde/3793234/fc8886120e45/anie0051-6103-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cde/3793234/7b3f8ab6494c/anie0051-6103-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cde/3793234/893acca509ae/anie0051-6103-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cde/3793234/1b4a53f2ba25/anie0051-6103-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cde/3793234/ef9072c728b2/anie0051-6103-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cde/3793234/fc8886120e45/anie0051-6103-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cde/3793234/7b3f8ab6494c/anie0051-6103-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cde/3793234/893acca509ae/anie0051-6103-f5.jpg

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Angew Chem Int Ed Engl. 2011 Apr 11;50(16):3755-9. doi: 10.1002/anie.201100310. Epub 2011 Mar 18.
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Nuclear magnetic resonance provides a quantitative description of protein conformational flexibility on physiologically important time scales.
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