利用核磁共振光谱和加速分子动力学研究CD2相关蛋白SH3结构域的多时间尺度构象动力学 - Suppr

Multi-timescale conformational dynamics of the SH3 domain of CD2-associated protein using NMR spectroscopy and accelerated molecular dynamics.

作者信息

Salmon Loïc, Pierce Levi, Grimm Alexander, Ortega Roldan Jose-Luis, Mollica Luca, Jensen Malene Ringkjøbing, van Nuland Nico, Markwick Phineus R L, McCammon J Andrew, Blackledge Martin

机构信息

Protein Dynamics and Flexibility, Institut de Biologie Structurale Jean-Pierre Ebel, CNRS-CEA-UJF, UMR 5075, 41 rue Jules Horowitz, 38027 Grenoble Cedex, France.

出版信息

Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6103-6. doi: 10.1002/anie.201202026. Epub 2012 May 8.

DOI:10.1002/anie.201202026

PMID:22565613

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3541011/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cde/3793234/1b4a53f2ba25/anie0051-6103-f1.jpg

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本文引用的文献

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J Biomol NMR. 2011 Jun;50(2):103-17. doi: 10.1007/s10858-011-9505-5. Epub 2011 Apr 26.

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Angew Chem Int Ed Engl. 2011 Apr 11;50(16):3755-9. doi: 10.1002/anie.201100310. Epub 2011 Mar 18.

Nuclear magnetic resonance provides a quantitative description of protein conformational flexibility on physiologically important time scales.核磁共振为蛋白质构象柔性在生理相关时间尺度上提供了定量描述。

Biochemistry. 2011 Apr 12;50(14):2735-47. doi: 10.1021/bi200177v. Epub 2011 Mar 21.

Toward a unified representation of protein structural dynamics in solution.迈向溶液中蛋白质结构动力学的统一表示。

J Am Chem Soc. 2009 Nov 25;131(46):16968-75. doi: 10.1021/ja907476w.

NMR spectroscopy brings invisible protein states into focus.NMR 光谱学将不可见的蛋白质状态聚焦。

Nat Chem Biol. 2009 Nov;5(11):808-14. doi: 10.1038/nchembio.238.

Protein conformational flexibility from structure-free analysis of NMR dipolar couplings: quantitative and absolute determination of backbone motion in ubiquitin.基于核磁共振偶极耦合无结构分析的蛋白质构象灵活性：泛素主链运动的定量与绝对测定

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Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution.溶液中由剩余偶极距耦合（RDC）得出的泛素系综揭示了直至微秒级的识别动力学。

Science. 2008 Jun 13;320(5882):1471-5. doi: 10.1126/science.1157092.

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Nature. 2007 Dec 6;450(7171):913-6. doi: 10.1038/nature06407. Epub 2007 Nov 18.

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Multi-timescale conformational dynamics of the SH3 domain of CD2-associated protein using NMR spectroscopy and accelerated molecular dynamics.

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