Center for Translational Medicine Research and Development, Institute of Biomedical and Health Engineering, Chinese Academy of Sciences, Shenzhen, China.
J Biomed Mater Res B Appl Biomater. 2012 Aug;100(6):1691-701. doi: 10.1002/jbm.b.32707. Epub 2012 May 7.
As a bioabsorbable metal with mechanical properties close to bone, pure magnesium or its alloys have great potential to be developed as medical implants for clinical applications. However, great efforts should be made to avoid its fast degradation in vivo for orthopedic applications when used for fracture fixation. Therefore, how to decease degradation rate of pure magnesium or its alloys is one of the focuses in Research and Development (R&D) of medical implants. It has been recognized that surface modification is an effective method to prevent its initial degradation in vivo to maintain its desired mechanical strength. This article reviews the recent progress in surface modifications for prevention of fast degradation of magnesium or its alloys using in vitro testing model, a fast yet relevant model before moving towards time-consuming and expensive in vivo testing. Pros and cons of various surface modifications are also discussed for the goal to design available products to be applied in clinical trials.
作为一种机械性能接近骨骼的可吸收金属，纯镁或其合金具有很大的潜力被开发为临床应用的医疗植入物。然而，为了避免其在用于骨折固定的骨科应用中体内快速降解，仍需要做出巨大努力。因此，如何降低纯镁或其合金的降解速度是医疗植入物研发的重点之一。人们已经认识到，表面改性是防止其体内初始降解以维持所需机械强度的有效方法。本文综述了使用体外测试模型（一种快速但相关的模型，先于耗时且昂贵的体内测试）预防镁或其合金快速降解的表面改性的最新进展。还讨论了各种表面改性的优缺点，旨在设计可用于临床试验的产品。
