School of Materials, Materials Science Centre, The University of Manchester, Manchester M1 7HS, UK.
Stem Cells Int. 2012;2012:303724. doi: 10.1155/2012/303724. Epub 2012 Feb 26.
Donor site morbidity, poor graft site integration, and incorrect mechanical performance are all common problems associated with autografts for anterior cruciate ligament (ACL) reconstructions. A tissue-engineered (TE) ligament has the potential to overcome these problems. We produced an online questionnaire relating to tissue engineering of the ACL to obtain input from practising clinicians who currently manage these injuries. 300 British orthopaedic surgeons specialising in knee surgery and soft tissue injury were invited to participate. 86% of surgeons would consider using a TE ACL if it were an option, provided that it showed biological and mechanical success, if it significantly improved the patient satisfaction (63%) or shortened surgical time (62%). 76% felt that using a TE ACL would be more appropriate than a patellar tendon, hamstring, or quadriceps autograft. Overall, most surgeons would be prepared to use a TE ACL if it were an improvement over the current techniques.
供体部位发病率高、移植物部位整合不良以及机械性能不正确,这些都是前交叉韧带(ACL)重建中自体移植物常见的问题。组织工程(TE)韧带有可能克服这些问题。我们制作了一份与 ACL 组织工程相关的在线问卷,以从目前处理这些损伤的执业临床医生那里获得意见。邀请了 300 名专门从事膝关节手术和软组织损伤的英国骨科医生参与。如果有这种选择,86%的医生会考虑使用 TE ACL,前提是它表现出生物和机械上的成功,如果它能显著提高患者满意度(63%)或缩短手术时间(62%)。76%的医生认为使用 TE ACL 比髌腱、腘绳肌或股四头肌自体移植物更合适。总的来说,如果 TE ACL 比现有技术有所改进,大多数医生都愿意使用它。