儿童急性白血病的一种特殊类型。
A special case of acute leukemia in childhood.
作者信息
Bleahu Ion Dorin, Vladasel Roxana, Gheorghe Anca
机构信息
Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy, Pediatrics Department, Bucharest, Romania.
出版信息
J Med Life. 2011 Aug 15;4(3):297-301. Epub 2011 Aug 25.
Hybrid leukemia is a clinical entity that includes: biphenotypic leukemia, characterized by the presence of markers of more than two lineages of a single tumor cell, bilineage leukemia, a combination of more than two lineage markers on two distinct blast cells, and biclonal leukemia, the concomitancy of more than two types of leukemic cells, derived from different clonal expansions. We present a case of a 7-year-old female diagnosed with bilineage leukemia. We propose a treatment for biphenotypic/bilineage leukemia in the cases with good prognostic factors. We suggest that hematopoietic stem cell transplantation is often not required for cure of these patients.
混合性白血病是一种临床实体，包括：双表型白血病，其特征为单个肿瘤细胞存在两种以上谱系的标志物；双谱系白血病，即两个不同原始细胞上存在两种以上谱系标志物的组合；以及双克隆白血病，即源自不同克隆扩增的两种以上类型白血病细胞的并存。我们报告一例7岁女性双谱系白血病病例。我们提出了针对具有良好预后因素的双表型/双谱系白血病的治疗方法。我们认为，治愈这些患者通常不需要进行造血干细胞移植。
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