Sturfelt G, Nived O, Norberg R, Thorstensson R, Krook K
Arthritis Rheum. 1987 Apr;30(4):382-8. doi: 10.1002/art.1780300404.
We studied a group of 59 unselected patients with systemic lupus erythematosus (SLE); these patients were from a defined population who lived in southern Sweden. We found that serum concentrations of anticardiolipin antibodies were increased in 32 SLE patients (54.2%). No significant correlation between increased amounts of anticardiolipin antibodies and clinical symptoms, such as thrombocytopenia or thrombosis, was found. Serial serum samples from 28 patients (12 patients were from the epidemiologic cohort) were analyzed. Sixteen of these 28 patients (57.1%) had increased levels of anticardiolipin antibodies; in most cases, there was no variation in these values with regard to clinical disease flares or treatment. Increased concentrations of anticardiolipin were observed in 4 patients with cerebral infarction. However, very high concentrations of anticardiolipin antibodies were observed in several patients with inactive SLE who had no history of thrombosis or thrombocytopenia. Our results underscore the importance of studying unselected patient groups when correlating laboratory data with clinical manifestations of disease.
我们研究了一组59例未经挑选的系统性红斑狼疮（SLE）患者；这些患者来自瑞典南部特定人群。我们发现，32例SLE患者（54.2%）的抗心磷脂抗体血清浓度升高。未发现抗心磷脂抗体量增加与血小板减少或血栓形成等临床症状之间存在显著相关性。对28例患者（12例来自流行病学队列）的系列血清样本进行了分析。这28例患者中有16例（57.1%）抗心磷脂抗体水平升高；在大多数情况下，这些值在临床疾病发作或治疗方面没有变化。4例脑梗死患者观察到抗心磷脂浓度升高。然而，在一些无血栓形成或血小板减少病史的非活动期SLE患者中观察到非常高浓度的抗心磷脂抗体。我们的结果强调了在将实验室数据与疾病临床表现相关联时研究未经挑选的患者群体的重要性。
