Keshtkar Ahmad, Salehnia Zeinab, Keshtkar Asghar, Shokouhi Behrooz
Medical Physics Department, Medical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran.
Patholog Res Int. 2012;2012:470101. doi: 10.1155/2012/470101. Epub 2012 Apr 9.
Bladder cancer is the fourth most common malignant neoplasm in men and the eighth in women. Bladder pathology is usually investigated visually by cystoscopy. In this technique, biopsies are obtained from the suspected area and then, after needed procedure, the diagnostic information can be taken. This is a relatively difficult procedure and is associated with discomfort for the patient and morbidity. Therefore, the electrical impedance spectroscopy (EIS), a minimally invasive screening technique, can be used to separate malignant areas from nonmalignant areas in the urinary bladder. The feasibility of adapting this technique to screen for bladder cancer and abnormalities during cystoscopy has been explored and compared with histopathological evaluation of urinary bladder lesions. Ex vivo studies were carried out in this study by using a total of 30 measured points from malignant and 100 measured points from non-malignant areas of patients bladders in terms of their biopsy reports matching to the electrical impedance measurements. In all measurements, the impedivity of malignant area of bladder tissue was significantly higher than the impedivity of non-malignant area this tissue (P < 0.005).
膀胱癌是男性中第四常见的恶性肿瘤，在女性中排第八。膀胱病理通常通过膀胱镜进行可视化检查。在这项技术中，从可疑区域获取活检样本，然后在进行必要的操作后，即可获取诊断信息。这是一个相对困难的过程，会给患者带来不适并引发并发症。因此，电阻抗光谱法（EIS）这种微创筛查技术可用于区分膀胱中的恶性区域和非恶性区域。人们已经探索了将该技术应用于膀胱镜检查中筛查膀胱癌及异常情况的可行性，并与膀胱病变的组织病理学评估进行了比较。在本研究中，根据活检报告与电阻抗测量结果的匹配情况，对患者膀胱的恶性区域共30个测量点和非恶性区域100个测量点进行了离体研究。在所有测量中，膀胱组织恶性区域的阻抗显著高于该组织非恶性区域的阻抗（P < 0.005）。
