Wlodarski K, Kobus M, Luczak M
Nature. 1979 Oct 4;281(5730):386-7. doi: 10.1038/281386a0.
Moloney murine sarcoma virus (M-MSV) induces at the site of inoculation in newborn and adult mice and rats various types of sarcoma, including osteosarcoma. The induced tumours are fatal in newborn, whereas sarcomas developed in adult animals regress spontaneously. The regression is mediated mainly by a cellular response. We have now demonstrated that the presence of sarcomas induced by M-MSV is a powerful stimulus for periosteal osteogenesis around tumour masses. Orthotopically induced osteogenesis by M-MSV may serve as a model for local regulation of bone growth and for cell differentiation studies, and may help explain the aetiology of some human bone disorders.
莫洛尼鼠肉瘤病毒（M-MSV）在新生及成年小鼠和大鼠的接种部位诱发各种类型的肉瘤，包括骨肉瘤。诱发的肿瘤在新生动物中是致命的，而成年动物中发生的肉瘤会自发消退。这种消退主要由细胞反应介导。我们现已证明，M-MSV诱发的肉瘤的存在是肿瘤周围骨膜成骨的强大刺激因素。M-MSV原位诱导成骨可作为骨生长局部调节及细胞分化研究的模型，并可能有助于解释某些人类骨疾病的病因。
