Le Gall C, Descos B, Roy P, Forichon J, Minaire Y, Hermier M
Unité de Gastroentérologie et de Nutrition Pédiatriques, Hôpital E.-Herriot, Lyon.
Arch Fr Pediatr. 1990 Aug-Sep;47(7):503-6.
Gastric acid secretion was studied in 17 children with primary duodenal ulcer (mean age: 10 yrs 4 mo, rang: 4-16). Eight of the 17 children with primary ulcer had chronic evolution and 10 of them had an affected first degree relative. Basal acid output (BAO) and peak acid output under pentagastrin (PAO) were not significantly different in the 17 children (0.094 +/- 0.085 mmol/kg/hr; 0.483 +/- 0.235 mmol/kg/hr) and in 32 adults with duodenal ulcer (0.073 +/- 0.010 mmol/kg/hr; 0.477 +/- 0.021 mmol/kg/hr). BAO and PAO were not significantly different between children with or without chronic ulcer. The BAO and PAO of children with an affected first degree relative were significantly higher than those of children without (p less than 0.05). This study shows that gastric acid secretions are similar in children and adults with duodenal ulcer. The chronicity of duodenal ulcer in childhood is not associated with increased acid secretion. Gastric acid secretion seems to be higher in children with an affected first degree relative than those without.
对17名原发性十二指肠溃疡患儿（平均年龄：10岁4个月，范围：4 - 16岁）的胃酸分泌情况进行了研究。17名原发性溃疡患儿中，8例病情呈慢性进展，其中10例有一级亲属患病。17名患儿的基础酸排量（BAO）和五肽胃泌素刺激后的最大酸排量（PAO）（分别为0.094±0.085 mmol/kg/小时；0.483±0.235 mmol/kg/小时）与32名十二指肠溃疡成人患者（分别为0.073±0.010 mmol/kg/小时；0.477±0.021 mmol/kg/小时）相比，无显著差异。有慢性溃疡和无慢性溃疡的患儿之间，BAO和PAO无显著差异。有一级亲属患病的患儿的BAO和PAO显著高于无一级亲属患病的患儿（p<0.05）。本研究表明，十二指肠溃疡患儿和成人的胃酸分泌情况相似。儿童十二指肠溃疡的慢性病程与胃酸分泌增加无关。有一级亲属患病的患儿的胃酸分泌似乎高于无一级亲属患病的患儿。
