Markiewicz K, Lukin M
Institut für Innere Medizin, Medizinischen Akademie Lódź.
Dtsch Z Verdau Stoffwechselkr. 1988;48(3-4):138-44.
In 22 men with chronic duodenal ulcer and 15 healthy men effect of a single intravenous injection of 2 mg of naloxone on basis and pentagastrin-stimulated acid output was determined. Naloxone was found to induce a significant decrease in BAO in chronic duodenal ulcer patients; a decrease in BAO in healthy men was insignificant. MAO was not affected by naloxone in both groups. Gastric secretions of potassium, sodium, chloride and mucoprotein were proportional to changes in the volume of the gastric juice. It seems that opioid agonists may play some role in the pathogenesis of duodenal ulcers.
对22名患有慢性十二指肠溃疡的男性和15名健康男性，测定了单次静脉注射2毫克纳洛酮对基础胃酸分泌量和五肽胃泌素刺激的胃酸分泌量的影响。结果发现，纳洛酮可使慢性十二指肠溃疡患者的基础胃酸分泌量显著降低；而在健康男性中，基础胃酸分泌量的降低并不显著。两组的最大胃酸分泌量均不受纳洛酮影响。胃液中钾、钠、氯和粘蛋白的分泌量与胃液量的变化成正比。阿片类激动剂似乎可能在十二指肠溃疡的发病机制中发挥一定作用。
