玻璃体内注射庆大霉素的视网膜毒性

Retinal toxicity of intravitreal gentamicin.

作者信息

Brown G C, Eagle R C, Shakin E P, Gruber M, Arbizio V V

机构信息

Retina Vascular Unit Service, Wills Eye Hospital, Thomas Jefferson University School of Medicine, Philadelphia, Pa.

出版信息

Arch Ophthalmol. 1990 Dec;108(12):1740-4. doi: 10.1001/archopht.1990.01070140094037.

DOI:10.1001/archopht.1990.01070140094037

PMID:2256847

Abstract

The short- and long-term effects of a 10-mg dose of intravitreal gentamicin were studied in the subhuman primate eye with regard to the changes in clinical appearance, fluorescein angiography, electroretinography, histopathologic finding, and electron microscopy. The gentamicin produced retinal whitening with a cherry-red spot, generalized vascular incompetence, diffuse retinal necrosis, thrombosis of the large retinal blood vessels, widespread loss of the retinal capillary pericytes and endothelial cells, and a rapid extinction of the electroretinogram.

摘要

研究了10毫克玻璃体内注射庆大霉素对非人灵长类动物眼睛的短期和长期影响，观察了其临床表现、荧光素血管造影、视网膜电图、组织病理学发现及电子显微镜检查的变化。庆大霉素导致视网膜变白并伴有樱桃红斑、全身性血管功能不全、弥漫性视网膜坏死、视网膜大血管血栓形成、视网膜毛细血管周细胞和内皮细胞广泛丧失，以及视网膜电图迅速消失。