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灵长类动物玻璃体内注射庆大霉素毒性的电子显微镜研究

Electron microscopic study of toxicity of intravitreal injections of gentamicin in primates.

作者信息

Ling C H, Peyman G A, Raichand M

出版信息

Can J Ophthalmol. 1985 Aug;20(5):179-83.

PMID:4041982
Abstract

Seven eyes of four young adult cynomolgus monkeys were injected intravitreally with 0.4 mg of gentamicin. One eye was enucleated after 1 day, and two eyes were enucleated after 1 week, 2 weeks and 1 month. The control eye received an intravitreal injection of 0.1 mL of saline and was enucleated after 1 week. All the eyes underwent electroretinography and ophthalmoscopy before and after treatment. No differences were detected by these techniques or by light and electron microscopy between the experimental eyes and the control.

摘要

给4只成年食蟹猴的7只眼睛玻璃体内注射0.4毫克庆大霉素。1只眼睛在1天后摘除,2只眼睛分别在1周、2周和1个月后摘除。对照眼玻璃体内注射0.1毫升生理盐水,1周后摘除。所有眼睛在治疗前后均进行了视网膜电图和检眼镜检查。通过这些技术以及光镜和电镜检查,未发现实验眼和对照眼之间存在差异。

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