Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, The People's Republic of China.
Invest Ophthalmol Vis Sci. 2012 Jun 20;53(7):3695-702. doi: 10.1167/iovs.11-9379.
To compare the retinal function of myopic children and young adults using the multifocal electroretinogram (mfERG).
Fifty-two children (aged 9-14 years) and 19 young adults (aged 21-28 years) with spherical equivalent refractive errors ranging from plano to -5.50 diopter (D) were recruited. They were examined using the global flash mfERG at 49% and 96% contrasts. Each local mfERG response was pooled into five concentric rings for analysis. The amplitudes and implicit times of direct components (DC) and induced components (IC) from the global flash response were analyzed. Hierarchical multiple regressions were used to evaluate the influence of refractive error and axial length on the DC and IC responses.
Compared with the emmetropes of the same age group, myopic children had a significant reduction in central macular DC response at 96% contrast while the IC response was unaffected, but myopic adults showed significant reductions in paracentral IC amplitudes at 49% contrast. Implicit times for DC and IC responses were unaffected for either group.
Retinal function was unaffected in myopic children, except for the outer retina in the central macular region. In contrast, the inner retinal function was substantially reduced in myopic adults, especially in the paracentral region. This study provides further evidence for different retinal, physiological characteristics in myopic children and myopic adults.
使用多焦视网膜电图（mfERG）比较近视儿童和年轻人的视网膜功能。
招募了 52 名儿童（9-14 岁）和 19 名年轻人（21-28 岁），他们的球镜等效屈光度范围从平光到-5.50 屈光度（D）。他们使用 49%和 96%对比度的全局闪烁 mfERG 进行检查。将每个局部 mfERG 响应分为五个同心环进行分析。分析了全局闪烁反应中直接成分（DC）和诱导成分（IC）的幅度和潜伏期。使用分层多元回归评估屈光不正和眼轴对 DC 和 IC 反应的影响。
与同年龄组的正视眼相比，近视儿童在 96%对比度时中央黄斑区 DC 反应明显降低，而 IC 反应不受影响，但近视成人在 49%对比度时周边 IC 振幅明显降低。两组的 DC 和 IC 反应潜伏期均不受影响。
除中央黄斑区外，近视儿童的视网膜功能不受影响，而近视成年人的内视网膜功能明显降低，尤其是周边区域。本研究为近视儿童和近视成年人的不同视网膜生理特征提供了进一步的证据。
