Chen Jennifer C, Brown Brian, Schmid Katrina L
School of Optometry and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Vision Res. 2006 Nov;46(24):4096-103. doi: 10.1016/j.visres.2006.07.033. Epub 2006 Sep 28.
Oscillatory potentials have been suggested to arise from the inner retina at the level of amacrine cells and inner plexiform layer and they are thought to provide a non-invasive assessment of inner retinal function. We sought to investigate the response dynamics of the inner retina of adult emmetropes and myopes by analysing the oscillatory potentials of the multifocal electroretinogram (mfERG) in these groups.
Eleven emmetropes and 18 myopes underwent mfERG testing using VERIS 5.1.5X. Myopes were further separated based on whether their myopia was stable (n=9) or progressing (n=9). Oscillatory potentials were recorded using a modified mfERG stimulation technique, the slow flash paradigm, and they were extracted using band-pass filtering from 100 to 300 Hz. The slow flash mfERG stimulus array consisted of 103-scaled hexagons and flickered according to a pseudorandom binary m-sequence (2(13)-1). Amplitudes and implicit times of the first-order oscillatory potentials were analysed.
There were significant differences in the implicit time of the oscillatory potentials of the emmetropes, stable myopes and progressing myopes (F(2,25)=3.663, p=0.043). Progressing myopes had significantly shorter implicit times compared to emmetropes (p=0.026 by 1.0-4.7 ms) and stable myopes (p=0.043 by 0.8-1.3 ms), whereas implicit times of stable myopes and emmetropes were similar. There were no statistically significant differences in amplitude of the oscillatory potentials between the groups (F(2,25)=0.890, p=0.426).
Significant differences in multifocal oscillatory potentials between stable and progressing myopes were found. This finding is further evidence of an inner retinal involvement in human myopia progression and may suggest an underlying alteration to dopaminergic or GABAergic retinal systems.
振荡电位被认为起源于无长突细胞和内网状层水平的视网膜内层，并且被认为可提供一种对内层视网膜功能的无创评估。我们试图通过分析这些组中多焦视网膜电图（mfERG）的振荡电位来研究正视成年人和近视成年人视网膜内层的反应动力学。
11名正视者和18名近视者使用VERIS 5.1.5X进行mfERG测试。近视者根据其近视是稳定的（n = 9）还是进展性的（n = 9）进一步分组。使用改良的mfERG刺激技术，即慢闪光范式记录振荡电位，并使用100至300Hz的带通滤波提取它们。慢闪光mfERG刺激阵列由103个缩放的六边形组成，并根据伪随机二进制m序列（2（13）-1）闪烁。分析了一阶振荡电位的振幅和隐含时间。
正视者、稳定近视者和进展性近视者的振荡电位隐含时间存在显著差异（F（2,25）= 3.663，p = 0.043）。与正视者（p = 0.026，相差1.0 - 4.7毫秒）和稳定近视者（p = 0.043，相差0.8 - 1.3毫秒）相比，进展性近视者的隐含时间明显更短，而稳定近视者和正视者的隐含时间相似。各组之间振荡电位的振幅没有统计学上的显著差异（F（2,25）= 0.890，p = 0.426）。
发现稳定近视者和进展性近视者之间的多焦振荡电位存在显著差异。这一发现进一步证明了视网膜内层参与人类近视进展，并且可能提示多巴胺能或GABA能视网膜系统存在潜在改变。
