Department of Kinesiology, College of Health and Human Performance, East Carolina University, Greenville, USA.
Nutr Metab (Lond). 2012 May 9;9(1):38. doi: 10.1186/1743-7075-9-38.
We have reported a reduction in fatty acid oxidation (FAO) at the whole-body level and in skeletal muscle in severely obese (BMI ≥ 40 kg/m2) individuals; this defect is retained in cell culture suggesting an inherent component. The purpose of the current study was to determine if an impairment in whole-body fatty acid oxidation (FAO) was also evident in children with a severely obese parent.
Substrate utilization during submaximal exercise (cycle ergometer) was determined in children ages 8-12 y with a severely obese parent (OP, n = 13) or two lean/non-obese (BMI range of 18 to 28 kg/m2) parents (LP, n = 13). A subgroup of subjects (n = 3/group) performed 4 weeks of exercise training with substrate utilization measured after the intervention.
The children did not differ in age (LP vs. OP, respectively) (10.7 ± 0.5 vs. 10.2 ± 0.5 y), BMI percentile (65.3 ± 5.2 vs. 75.9 ± 7), Tanner Stage (1.4 ± 0.2 vs. 1.5 ± 0.2), VO2peak (40.3 ± 2.7 vs. 35.6 ± 2.6 ml/kg/min) or physical activity levels (accelerometer). At the same absolute workload of 15 W (38% VO2peak), RER was significantly (P ≤ 0.05) lower in LP vs. OP (0.83 ± 0.02 vs. 0.87 ± 0.01) which was reflected in a reduced reliance on FAO for energy production in the OP group (58.6 ± 5.1 vs. 43.1 ± 4.0% of energy needs during exercise from FAO). At a higher exercise intensity (65% VO2peak) there were no differences in substrate utilization between LP and OP. After exercise training RER tended to decrease (P = 0.06) at the 15 W workload, suggesting an increased reliance on FAO regardless of group.
These findings suggest that the decrement in FAO with severe obesity has an inherent component that may be overcome with exercise training.
我们曾报道过，严重肥胖（BMI≥40kg/m2）人群的全身脂肪酸氧化（FAO）和骨骼肌中的 FAO 减少，这一缺陷在细胞培养中仍然存在，提示这是固有成分。本研究的目的是确定严重肥胖父母的儿童是否也存在全身脂肪酸氧化（FAO）受损的情况。
8-12 岁严重肥胖父母（OP，n=13）或两个瘦/不肥胖（BMI 范围 18 至 28kg/m2）父母（LP，n=13）的儿童在进行次最大强度运动（脚踏车测功计）时，测定底物的利用情况。亚组受试者（n=3/组）进行了 4 周的运动训练，干预后测定底物的利用情况。
儿童的年龄（LP 与 OP 分别）（10.7±0.5 岁与 10.2±0.5 岁）、BMI 百分位数（65.3±5.2 与 75.9±7）、Tanner 分期（1.4±0.2 与 1.5±0.2）、VO2peak（40.3±2.7 与 35.6±2.6ml/kg/min）或体力活动水平（加速度计）均无差异。在相同的绝对工作负荷 15W（38%VO2peak）下，LP 的呼吸商（RER）显著低于 OP（0.83±0.02 与 0.87±0.01）（P≤0.05），这反映在 OP 组中，FAO 对能量产生的依赖减少（运动时 FAO 提供的能量需求占 58.6±5.1%，而非 43.1±4.0%）。在更高的运动强度（65%VO2peak）下，LP 和 OP 之间的底物利用没有差异。运动训练后，15W 工作负荷时 RER 有下降的趋势（P=0.06），提示无论组别如何，对 FAO 的依赖增加。
这些发现表明，严重肥胖导致的 FAO 减少具有固有成分，通过运动训练可能会得到克服。
