School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, South Korea.
Biomaterials. 2012 Aug;33(22):5650-7. doi: 10.1016/j.biomaterials.2012.04.033. Epub 2012 May 8.
Magnetic nanoparticles are widely used in bioapplications such as imaging and targeting tool. Their magnetic nature allows for the more efficient bioapplications by an external field gradient. However their combined effects have not yet been extensively characterized. Herein, we first demonstrate the biological effects of the communications between internalized bacterial magnetic nanoparticles (BMPs) and an external static magnetic field (SMF) on a standard human cell line. Combination of the BMPs and SMF act as the key factor leading to the alteration of cell structure and the enhanced cell growth. Also, their interaction reduced the apoptotic efficiency of human tumor cells induced by anticancer drugs. Microarray analysis suggests that these phenomena were caused by the alterations of GPCRs-mediated signal transduction originated in the interaction of internalized BMPs and the external SMF. Our findings may offer new approach for targeted cell therapy with the advantage of controlling cell viability by magnetic stimulation.
磁性纳米粒子在生物应用中得到了广泛的应用，例如成像和靶向工具。它们的磁性性质允许通过外部磁场梯度更有效地进行生物应用。然而，它们的综合效应尚未得到广泛的描述。在这里，我们首先证明了内吞细菌磁性纳米粒子（BMPs）与外部静态磁场（SMF）之间的通信对标准人类细胞系的生物学效应。BMPs 和 SMF 的组合是导致细胞结构改变和增强细胞生长的关键因素。此外，它们的相互作用降低了抗癌药物诱导的人类肿瘤细胞的凋亡效率。微阵列分析表明，这些现象是由内吞 BMPs 与外部 SMF 的相互作用引起的 GPCRs 介导的信号转导的改变引起的。我们的研究结果为靶向细胞治疗提供了新的途径，其优势是通过磁刺激控制细胞活力。
