Interdisciplinary Program of Bioengineering, Seoul National University, San 56-1, Shinlim, Kwanak, Seoul, 151-742, Korea.
Chem Commun (Camb). 2012 Aug 4;48(60):7474-6. doi: 10.1039/c2cc33659f. Epub 2012 Jun 25.
We first demonstrate the effects of magnetic trapping of mitochondria using aptamer conjugated to bacterial magnetic nanoparticles that allowed targeting of the mitochondrial cytochrome c in the treatment of cancer cells. Our findings offer a new approach for targeted cell therapy, with the advantage of remote control over subcellular elements.
我们首先展示了使用与细菌磁性纳米颗粒偶联的适体来实现线粒体磁捕获的效果，该适体能够靶向线粒体细胞色素 c，用于治疗癌细胞。我们的研究结果为靶向细胞治疗提供了一种新方法，具有对亚细胞元件进行远程控制的优势。
