Yu V Y, Lim C T, Downe L M
Department of Paediatrics, Monash Medical Centre, Melbourne, Victoria, Australia.
J Paediatr Child Health. 1990 Aug;26(4):205-8. doi: 10.1111/j.1440-1754.1990.tb02430.x.
This study reported the prevalence and severity of retinopathy of prematurity (ROP) in less than or equal to 28 weeks gestation or less than or equal to 1000 g birthweight infants over a 12-year period. Among 328 survivors of less than or equal to 28 weeks gestation, 30% had ROP, 12% had severe ROP of Stage 3 or worse, 5% had at least one blind eye and 3% were bilaterally blind. Among 201 survivors of less than or equal to 1000 g birthweight, the above abnormalities were found in 40, 16, 6 and 4% respectively. In both cohorts there was a significant increase in the prevalence of ROP and severe ROP between the period 1977-80 and 1981-84, but the lesser increase observed between the periods 1981-84 and 1985-88 was not statistically significant. The rates of ROP-induced blindness were not significantly different between the three 4-year periods. An inverse relationship was noted between the prevalence of ROP and gestational age. The results suggest a resurgence of ROP in less than or equal to 28 weeks or less than or equal to 1000 g infants, the cause of which is uncertain. In view of this trend, continued surveillance of ROP is warranted.
本研究报告了孕周小于或等于28周或出生体重小于或等于1000克的婴儿在12年期间早产儿视网膜病变（ROP）的患病率和严重程度。在孕周小于或等于28周的328名存活婴儿中，30%患有ROP，12%患有3期或更严重的严重ROP，5%至少有一只眼睛失明，3%双眼失明。在出生体重小于或等于1000克的201名存活婴儿中，上述异常的发生率分别为40%、16%、6%和4%。在两个队列中，1977 - 1980年期间与1981 - 1984年期间相比，ROP和严重ROP的患病率均显著增加，但1981 - 1984年期间与1985 - 1988年期间相比观察到的较小增幅无统计学意义。ROP导致失明的发生率在三个4年期间无显著差异。ROP患病率与孕周呈负相关。结果表明，孕周小于或等于28周或出生体重小于或等于1000克的婴儿中ROP有所复发，其原因尚不确定。鉴于这一趋势，有必要继续对ROP进行监测。
