Department of Psychiatry, Behavioral Health and Neuroscience, University of North Texas, Health Sciences Center, Fort Worth, TX 76107, USA.
J Alzheimers Dis. 2012;31(2):429-37. doi: 10.3233/JAD-2012-111481.
Functional impairment is common in Alzheimer's disease (AD) and related to increased caregiver burden and institutionalization. There is a dearth of research investigating the relationship between specific biomarkers and basic activities of daily living (BADLs) such as toileting, feeding, dressing, grooming, bathing, and ambulating. The present study examined the relationship between serum based biomarkers and specific ADLs in a sample of AD patients. Data were collected from 196 participants enrolled in the Texas Alzheimer's Research and Care Consortium Project and diagnosed with AD. BADLs were measured using the Lawton-Brody Physical Self-Maintenance Scale. A panel of 22 biomarkers previously found to be related to AD pathology was used for the analysis. Stepwise regression modeling was used to assess the link between the biomarkers and BADLs. Results were also examined by gender. Nine of the 22 biomarkers were significantly related to BADLs. When stratified by gender, the biomarkers accounted for 32% of the variance in the males and 27% in females. The pattern of significant biomarkers differed by gender with IL 7 and Tenascin C significantly related to BADLs for females and IL 15 significantly related to BADLs for males. The results of this study indicated that a small number of serum based biomarkers are related to BADLs, and these biomarkers differed by gender.
功能障碍在阿尔茨海默病（AD）中很常见，与增加照顾者负担和住院有关。缺乏研究调查特定生物标志物与日常生活活动（BADLs）之间的关系，如如厕、进食、穿衣、修饰、洗澡和行走。本研究在 AD 患者样本中检查了血清生物标志物与特定 ADL 之间的关系。数据来自德克萨斯州阿尔茨海默病研究和护理联盟项目的 196 名参与者，这些参与者被诊断患有 AD。BADLs 使用 Lawton-Brody 身体自我维持量表进行测量。使用先前发现与 AD 病理相关的 22 种生物标志物进行分析。逐步回归模型用于评估生物标志物与 BADLs 之间的联系。结果还按性别进行了检查。22 种生物标志物中有 9 种与 BADLs 显著相关。按性别分层时，这些生物标志物在男性中占 32%，在女性中占 27%。性别之间显著生物标志物的模式不同，女性中 IL-7 和 Tenascin C 与 BADLs 显著相关，男性中 IL-15 与 BADLs 显著相关。这项研究的结果表明，少数几种血清生物标志物与 BADLs 相关，并且这些生物标志物因性别而异。
