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胰腺癌根治性切除术后13年发生转移性肺腺癌:1例报告并复习日本文献

Metastatic pulmonary adenocarcinoma 13 years after curative resection for pancreatic cancer: report of a case and review of Japanese literature.

作者信息

Kitasato Yuhei, Nakayama Masamichi, Akasu Gen, Yoshitomi Munehiro, Mikagi Kazuhiro, Maruyama Yuichiro, Kawahara Ryuichi, Ishikawa Hiroto, Hisaka Toru, Yasunaga Masafumi, Horiuchi Hiroyuki, Saito Naoyuki, Takamori Shinzo, Okabe Yoshinobu, Kage Masayoshi, Kinoshita Hisafumi, Tanaka Hiroyuki

机构信息

Department of Surgery, Kurume University School of Medicine, Kurume, Japan.

出版信息

JOP. 2012 May 10;13(3):296-300.

Abstract

CONTEXT

For the majority of patients, ductal adenocarcinoma of the pancreas remains a lethal disease. Currently, surgical extirpation for localized disease offers the only chance for long-term survival.

CASE REPORT

We report a patient who underwent successful resection of isolated lung metastasis occurring 13 years after pancreatic cancer resection. A 59-year-old woman underwent distal pancreatectomy for pancreatic cancer 13 years previously, followed by adjuvant chemotherapy, and was followed-up at the outpatient clinic of a local hospital. From around June 2010, she noticed bloody sputum, so she visited a local hospital. Since her chest X-ray and CT revealed a 1.5 cm mass shadow in the segment 10 of her right lung and she was referred to the Respiratory Disease Center of our hospital. As a result of through examinations, she was strongly suspected of having lung metastasis of pancreatic cancer, and underwent partial pneumonectomy. Postoperative histopathological examination of the resected specimen was consistent with lung metastasis of pancreatic cancer. She is still alive and currently receives third line of chemotherapy.

CONCLUSION

Patients who have achieved long-term survival after pancreatic cancer resection and can tolerate surgery may benefit from resection of a lung metastasis of pancreatic cancer in terms of survival, if it controls the metastasis.

摘要

背景

对于大多数患者而言,胰腺导管腺癌仍然是一种致命疾病。目前,针对局限性疾病的手术切除是获得长期生存的唯一机会。

病例报告

我们报告了一例患者,其在胰腺癌切除术后13年发生孤立性肺转移并成功切除。一名59岁女性13年前因胰腺癌接受了远端胰腺切除术,随后接受辅助化疗,并在当地医院门诊随访。从2010年6月左右开始,她注意到痰中带血,因此前往当地医院就诊。由于其胸部X线和CT显示右肺10段有一个1.5厘米的肿块阴影,她被转诊至我院呼吸疾病中心。经过全面检查,她被高度怀疑患有胰腺癌肺转移,并接受了部分肺切除术。切除标本的术后组织病理学检查与胰腺癌肺转移相符。她仍然存活,目前正在接受三线化疗。

结论

胰腺癌切除术后获得长期生存且能够耐受手术的患者,如果手术能够控制转移,那么从生存角度而言,切除胰腺癌肺转移灶可能有益。

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