Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR.
Chem Commun (Camb). 2012 Jun 14;48(47):5850-2. doi: 10.1039/c2cc31689g. Epub 2012 May 9.
Several intermediates and different reaction paths were identified for the acid catalysed conversion of fructose to 5-(hydroxymethyl)-2-furaldehyde (HMF) in different solvents. The structural information combined with results of isotopic-labelling experiments allowed the determination of the irreversibility of the three steps from the fructofuranosyl oxocarbenium ion to HMF as well as the analogous pyranose route.
在不同溶剂中，酸催化果糖转化为 5-(羟甲基)-2-糠醛（HMF）的过程中确定了几个中间体和不同的反应途径。结构信息结合同位素标记实验的结果，确定了从呋喃果糖氧碳鎓离子到 HMF 以及类似的吡喃糖途径的三个步骤的不可逆性。
