Lacey J H, Crisp A H, Hart G, Kirkwood B A
Postgrad Med J. 1979 Jun;55(644):381-5. doi: 10.1136/pgmj.55.644.381.
The carpal bones of 18 anorexia nervosa patients were radiographed and the X-ray age assessed by 2 different standard methods. The study demonstrates that skeletal development in anorexia nervosa patients is delayed such that there is no association between radiological assessment of age and chronological age. It is strongly suggested that bony development actually ceases when body weight falls sufficiently to stop menstruation. There was a highly significant (P = 0.001) linear relationship between radiological age and the sum of the age of onset of the illness plus any period(s) of re-feeding. Weight gain seems to re-kindle the bone maturing mechanisms: the role of weight thresholds and associated hormone activity being discussed. The findings of this study strongly support the existing evidence that the anorexia nervosa patient is biologically and psychologically immature.
对18名神经性厌食症患者的腕骨进行了X光检查，并通过两种不同的标准方法评估了X线年龄。该研究表明，神经性厌食症患者的骨骼发育延迟，因此年龄的放射学评估与实际年龄之间没有关联。强烈建议当体重下降到足以停止月经时，骨骼发育实际上就会停止。放射学年龄与发病年龄加上任何再喂养期的总和之间存在高度显著的线性关系（P = 0.001）。体重增加似乎会重新激活骨骼成熟机制：文中讨论了体重阈值和相关激素活性的作用。这项研究的结果有力地支持了现有证据，即神经性厌食症患者在生理和心理上都不成熟。
