Frisch R E, McArthur J W
Science. 1974 Sep 13;185(4155):949-51. doi: 10.1126/science.185.4155.949.
Weight loss causes loss of menstrual function (amenorrhea) and weight gain restores menstrual cycles. A minimal weight for height necessary for the onset of or the restoration of menstrual cycles in cases of primary or secondary amenorrhea due to undernutrition is indicated by an index of fatness of normal girls at menarche and at age 18 years, respectively. Amenorrheic patients of ages 16 years and over resume menstrual cycles after weight gain at a heavier weight for a particular height than is found at menarche. Girls become relatively and absolutely fatter from menarche to age 18 years. The data suggest that a minimum level of stored, easily mobilized energy is necessary for ovulation and menstrual cycles in the human female.
体重减轻会导致月经功能丧失（闭经），体重增加则会使月经周期恢复。因营养不良导致原发性或继发性闭经的情况下，月经周期开始或恢复所需的身高最低体重，分别由正常女孩初潮时和18岁时的肥胖指数表明。16岁及以上的闭经患者体重增加后恢复月经周期时，相对于初潮时特定身高的体重，此时的体重更重。女孩从初潮到18岁会相对和绝对地变胖。数据表明，人体女性排卵和月经周期需要最低水平的储存且易于调动的能量。
