Cho Hanjoung, Bae Jungeun, Garripelli Vivek K, Anderson Joel M, Jun Ho-Wook, Jo Seongbong
Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Chem Commun (Camb). 2012 Jun 18;48(48):6043-5. doi: 10.1039/c2cc31463k. Epub 2012 May 10.
Bioresponsive polymeric nanoparticles have been extensively pursued for the development of tumor-targeted drug delivery. A novel redox-sensitive biodegradable polymer with "trimethyl-locked" benzoquinone was synthesized for the preparation of paclitaxel-incorporated nanoparticles. The synthesized redox-sensitive nanoparticles released paclitaxel in response to chemically triggered reduction.
生物响应性聚合物纳米颗粒已被广泛用于肿瘤靶向药物递送的研发。合成了一种带有“三甲基锁定”苯醌的新型氧化还原敏感型可生物降解聚合物，用于制备负载紫杉醇的纳米颗粒。合成的氧化还原敏感型纳米颗粒在化学触发的还原反应下释放紫杉醇。
