科罗拉多州和内布拉斯加州农业工人中潜在易感亚组的肺功能降低。
Pulmonary function reductions among potentially susceptible subgroups of agricultural workers in Colorado and Nebraska.
机构信息
Department of Environmental and Radiological Health Sciences, Colorado State University, Ft. Collins, CO 80523, USA.
出版信息
J Occup Environ Med. 2012 May;54(5):632-41. doi: 10.1097/JOM.0b013e31824d2e1c.
OBJECTIVE
Organic dust inhalation has been associated with adverse respiratory responses among agricultural workers. We evaluated factors that may confer increased susceptibility to these health effects.
METHODS
We quantified personal work shift exposures to inhalable dust, endotoxin, and its 3-hydroxy fatty acid constituents, and evaluated changes in pulmonary function among 137 grain elevator, cattle feedlot, dairy, and corn farm workers.
RESULTS
Increased dust exposure was associated with work shift reductions in lung function. Although interpretation is limited because of small samples, a suggestion of stronger exposure-response relationships was observed among smokers, as well as workers reporting pesticide/herbicide application, asthma, or allergies, and those with genetic polymorphisms (TLR4) (Pinteraction ≤ 0.05).
CONCLUSIONS
A better understanding of factors leading to increased susceptibility of adverse respiratory outcomes is needed to optimize exposure reduction strategies and develop more comprehensive wellness programs.
目的
有机粉尘吸入与农业工人的不良呼吸道反应有关。我们评估了可能增加对这些健康影响易感性的因素。
方法
我们量化了 137 名谷物升降机、牛饲养场、奶牛场和玉米农场工人个人工作班次的可吸入粉尘、内毒素及其 3-羟基脂肪酸成分的暴露，并评估了肺功能的变化。
结果
粉尘暴露的增加与工作班次肺功能的降低有关。尽管由于样本量小，解释受到限制，但在吸烟者、报告使用农药/除草剂、哮喘或过敏以及具有遗传多态性（TLR4）的工人中观察到更强的暴露-反应关系（P 交互作用≤0.05）。
结论
需要更好地了解导致不良呼吸道结果易感性增加的因素，以优化暴露减少策略并制定更全面的健康计划。
Zotero 插件