Bron A, Talon D, Cellier T, Estavoyer J M, Delbosc B, Royer J
Service Ophtalmologie, Hôpital Jean Minjoz, Besançon.
Bull Soc Ophtalmol Fr. 1990 Aug-Sep;90(8-9):805-6, 809-11.
The intraocular penetration of Ciprofloxacin in man: authors have studied the penetration of Ciprofloxacin in the aqueous humor of 30 patients (30 eyes). The concentration in the anterior chamber was on average 0.73 mg/l which is 33% of serum level, from 1.30 hours after a single oral dose of 1000 mg till the 4th hour after this dose. The samples were assessed by a microbiological method. These results are over the minimal inhibitory concentration for many bacterial agents found in endophthalmitis. So this antibiotic may be proposed in the treatment of endophthalmitis. Anyway further investigation is mandatory to assess the safety on efficacy of these antibiotics.
作者研究了环丙沙星在30例患者（30只眼）房水中的渗透性。单次口服1000mg后1.30小时至该剂量后第4小时，前房内浓度平均为0.73mg/L，为血清水平的33%。样本通过微生物学方法评估。这些结果超过了眼内炎中发现的许多细菌病原体的最低抑菌浓度。因此，这种抗生素可用于眼内炎的治疗。无论如何，必须进一步研究以评估这些抗生素的安全性和有效性。
