局部用0.3%环丙沙星在人房水中的渗透情况。
Penetration of topical 0.3% ciprofloxacin into human aqueous humor.
作者信息
Kalayci D, Basci N, Akpek E, Hasiripi H, Bozkurt A
机构信息
Department of Ophthalmology, Numune State Research and Training Hospital, Ankara, Turkey.
出版信息
Ophthalmic Surg Lasers. 1996 Jan;27(1):21-4.
BACKGROUND AND OBJECTIVE
Investigation of the penetration of topical ciprofloxacin into aqueous humor.
PATIENTS AND METHODS
Topical 0.3% ciprofloxacin drops were administered to 17 patients with cataracts before lens extraction surgery. The time interval between the first dose and sampling was 3 hours in 9 patients (group A) and 6 hours in 8 (group B). In both groups, aqueous samples were collected 30 minutes after the last ciprofloxacin application. Ciprofloxacin concentration was determined by high-performance liquid chromatography-fluorescence detection.
RESULTS
Mean aqueous concentration was 0.83+/-0.48 microgram/ml in group A and 2.42+/-1.42 micrograms/ml in group B.
CONCLUSION
Topical 0.3% ciprofloxacin penetrates into the aqueous in a significant concentration.
背景与目的
研究局部应用环丙沙星在房水中的渗透情况。
患者与方法
17例白内障患者在晶状体摘除术前局部应用0.3%环丙沙星滴眼液。9例患者（A组）首剂用药至采样的时间间隔为3小时，8例患者（B组）为6小时。两组均在最后一次应用环丙沙星30分钟后采集房水样本。采用高效液相色谱-荧光检测法测定环丙沙星浓度。
结果
A组房水平均浓度为0.83±0.48微克/毫升，B组为2.42±1.42微克/毫升。
结论
局部应用0.3%环丙沙星能以显著浓度渗透至房水中。
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