Johannisson E
Clinic of Sterility and Gynecologic Endocrinology, Department of Obstetrics & Gynecology, Geneva, Switzerland.
Contraception. 1990 Oct;42(4):403-21. doi: 10.1016/0010-7824(90)90049-2.
Some conflicting reports have appeared in the literature as to the effect of progestogens on the endometrium and on the endo- and exocervix in animals and humans. Hyperplasia of the endometrial and endocervical epithelium has been reported in some non-human primates following the administration of progestogens. In other studies no evidence has been found for such changes. In women using combined oral contraceptives, it has been claimed that the progestogen component causes adenomatous hyperplasia of the endocervix and that this hyperplastic transformation could be a precursor to adenocarcinoma of the cervix. So far, there is, however, no evidence in the literature to confirm this hypothesis. In view of the development of new delivery systems with a constant release of small amounts of progestogens, previous reports in the literature on hyperplasia and potential malignant transformation of the endometrium and the endocervix have been a matter of concern. The aim of the present study is therefore to review results from studies in animals and humans in particular with reference to the effect of a local release of various progestogens on the endometrium and the endo- and exocervix.
关于孕激素对动物和人类子宫内膜以及子宫颈内膜和外宫颈的影响，文献中出现了一些相互矛盾的报道。在一些非人灵长类动物中，使用孕激素后出现了子宫内膜和宫颈上皮增生的报道。在其他研究中，未发现此类变化的证据。在使用复方口服避孕药的女性中，有人声称孕激素成分会导致宫颈腺瘤样增生，并且这种增生性转变可能是宫颈癌的先兆。然而，迄今为止，文献中没有证据证实这一假设。鉴于新的能持续释放少量孕激素的给药系统的发展，以往文献中关于子宫内膜和宫颈增生及潜在恶性转化的报道一直令人担忧。因此，本研究的目的是回顾动物和人类研究的结果，特别是关于各种孕激素局部释放对子宫内膜以及子宫颈内膜和外宫颈的影响。
