Taghian Farzaneh, Esteki Ghashghaei Fatemeh, Badami Rokhsareh, Esteki Ghashghaei Samira
PhD, Assistant Professor of Exercise Physiology, Department of Physical Educationa and Sport Sciences, Khorasgan Branch, Islamic Azad University, Isfahan, Iran.
ARYA Atheroscler. 2011 Winter;6(4):153-6.
Cytokines are a group of low-molecular-weight regulatory proteins that produced by cells in response to stimulation. In fact, they increase in response to immune system during exercise. Also, many cytokines such as IL-6 and TNFα are secreted from adipose tissue in obese people. So the aim of this study was to investigate the effect of one session submaximal exercise on plasma levels of IL6 and TNFα in obese and non-obese women.
Sixteen healthy women aged 20-30 years old participated in the study. Subjects were classified into obese (n=8) and nonobese (n=8) groups who performed submaximal exercise program (50-65% HRM) for 30minutes. Blood samples were taken for cytokines measurement, before and after exercise. Data were analyzed with SPSS15. The effect of exercise on mentiones variables was evaluated using t-test and covariance test.
Level of IL-6 increased significantly in two studied groups after 30 minutes submaximal exercise (P<0.05). Levels of TNFα increased significantly in obese subjects but not in non-obese subjects. There were no significant changes in the levels of IL-6 and TNFα after 30 minutes submaximal exercise between two studied groups (P>0.05).
After submaximal exercise, plasma level of IL6 and TNFα may increase and adipose tissue is the main source of circulating IL6 and TNFα.
细胞因子是一组由细胞在受到刺激后产生的低分子量调节蛋白。事实上，它们在运动过程中会随着免疫系统的反应而增加。此外，许多细胞因子，如白细胞介素-6（IL-6）和肿瘤坏死因子α（TNFα），在肥胖人群的脂肪组织中分泌。因此，本研究的目的是调查一次亚极量运动对肥胖和非肥胖女性血浆中IL-6和TNFα水平的影响。
16名年龄在20 - 30岁的健康女性参与了该研究。受试者被分为肥胖组（n = 8）和非肥胖组（n = 8），两组均进行了30分钟的亚极量运动项目（心率储备的50 - 65%）。在运动前后采集血样用于细胞因子测量。数据用SPSS15进行分析。使用t检验和协方差检验评估运动对上述变量的影响。
在进行30分钟亚极量运动后，两个研究组的IL-6水平均显著升高（P < 0.05）。肥胖受试者的TNFα水平显著升高，而非肥胖受试者则未升高。两个研究组在进行30分钟亚极量运动后，IL-6和TNFα水平无显著变化（P > 0.05）。
亚极量运动后，血浆中IL-6和TNFα水平可能升高，且脂肪组织是循环中IL-6和TNFα的主要来源。
